XENON-BASED ANESTHETIC GAS COMPOSITION USABLE DURING AN ENDARTERECTOMY INVOLVING THE CLAMPING OF THE CAROTID ARTERY

摘要

A xenon-based anesthetic gas to be used, via inhalation, to maintain or preserve cerebral perfusion during an endarterectomy involving the clamping of the carotid artery in a mammal under general anesthesia. The xenon is preferably used in combination with at least one injectable anesthetic morphine agent such as remifentanil, sulfentanil, fentanyl, and alfentanil. Advantageously, the xenon is mixed with an oxygen-containing gas and administered to the patient after the patient has been anesthetized, put to sleep, and intubated. The use of xenon makes it possible to achieve a reduction in the pressure gradient during the clamping of the internal carotid artery relative to the usual anesthetic agents, and to achieve stable hemodynamics.

主权项

1. A method of maintaining cerebral perfusion during an endarterectomy involving the clamping of the carotid artery in a mammal under general anesthesia comprising the steps of
a) providing an effective amount of a xenon gas composition via inhalation to a mammal under general anesthesia during the endarterectomy involving the clamping of the carotid artery to thereby maintaining cerebral perfusion during the endarterectomy involving the clamping of the carotid artery, b) providing at least one injectable anesthetic agent to the mammal, and c) providing at least one hypnotic agent which is injected intravenously or administered by inhalation.