BIODEGRADABLE ALPHA-2 AGONIST POLYMERIC IMPLANTS AND THERAPEUTIC USES THEREOF

摘要

Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

主权项

1. A biodegradable implant adapted for intraocular use, the implant comprising:
(a) more than 50 weight percent alpha-2 adrenergic receptor agonist, and; (b) a biodegradable polymer which is a mixture of;
(i) an ester end-capped poly (D,L-lactide) polymer, and(ii) an ester end-capped poly (D,L-lactide-co-glycolide) polymer.