| 摘要 |
PROBLEM TO BE SOLVED: To solve the following problem: compounds of formula I as defined in the invention are found sensitive to certain excipients, which may cause decomposition of the compounds of formula I and/or lack of stability of the compositions and formulations containing these compounds; and the compounds of formula I may also exhibit a low bulk density and/or poor flow characteristics, which may increase the difficulty in formulating and/or manufacturing a stable dosage formulation containing the active compound.SOLUTION: The present disclosure relates to: compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined in the invention and salts, esters, hydrates, solvates and other derivatives thereof; and methods of making the same.SELECTED DRAWING: None |
