Stable Aqueous Formulations of Adalimumab

摘要

The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

主权项

1. An aqueous formulation of adalimumab comprising:
(a) adalimumab; (b) a buffer selected from the group consisting of citrate, phosphate, histidine, succinate, tartrate, maleate and acetate, and combinations thereof, provided the combinations do not include a combination of citrate buffer and phosphate buffer; (c) a polyol; and (d) a surfactant, wherein the formulation has pH of 4 to 8.