COMPOSITIONS FOR PREVENTING AND/OR TREATING AN INFECTION BY AN HIV-1 VIRUS

摘要

The present invention relates to an immunogenic composition comprising an antigenic peptide of formula (I) below: Nt-S-X1-X2-X3-K-X4-Ct (I) [SEQ ID No 1], wherein —Nt consists of a peptide having from 0 to 50 amino acids in length, —Ct consists of a peptide having from 0 to 50 amino acids in length, —each of X1 to X4 consists of an amino acid residue, wherein: —(i) X1 means the specific amino acid W or (ii) X1 means any amino acid residue excepted W, —(i) X2 means the specific amino acid S or (ii) X2 means any amino acid residue excepted S, —(i) X3 means the specific amino acid N or (ii) X3 means any amino acid residue excepted N, —(i) X4 means the specific amino acid S or (ii) X4 means any amino acid residue excepted S, with the proviso that —three out of the four amino acid residues X1, X2, X3 and X4 mean the specific amino acid defined in their respective meaning (i) above, and —the remaining amino acid residue among X1 to X4 means any amino acid residue excepted the specific amino acid residue defined in its meaning (i), for preventing and/or treating an infection of an individual with an HIV-1 virus.

主权项

1. An immunogenic composition comprising an antigenic peptide of Formula I:Formula I(I)[Nt-SEQ ID No 1-Ct]Nt-S-X1-X2-X3-K-X4-Ct wherein
Nt comprises a peptide of from 0 to 50 amino acids in length,Ct comprises a peptide of from 0 to 50 amino acids in length, andeach of X1 to X4 is an amino acid residue, wherein:
(i) X1 is the specific amino acid W or (ii) X1 is any amino acid residue except W,(i) X2 is the specific amino acid S or (ii) X2 is any amino acid residue except S,(i) X3 is the specific amino acid N or (ii) X3 is any amino acid residue except N,(i) X4 is the specific amino acid S or (ii) X4 is any amino acid residue except S,with the proviso that
three out of the four amino acid residues X1, X2, X3 and X4 are an amino acid as defined in (i) above, andthe remaining amino acid residue is any amino acid residue except the amino acid residue as defined in (i), and wherein the antigenic peptide is not the peptide of SEQ ID No 16.