METHODS OF TREATING B2-BRADYKININ RECEPTOR MEDIATED ANGIOEDEMA

摘要

Methods of treating B2-bradykinin receptor mediated angioedema in a subject by administering a composition containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof. Oral formulations containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof for the treatment of B2-bradykinin receptor mediated angioedema. Use of a composition containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof for the manufacture of a medicament for the treatment and/or prevention of a B2-bradykinin receptor mediated angioedema.

主权项

1. A method of treating a B2-bradykinin receptor mediated angioedema in a subject comprising:
administering to the subject in need thereof a therapeutically effective amount of a composition comprising a compound having formula (I) or a pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate thereofwherein R1 isH orwherein R2 iswherein R3 is Cl or CN;wherein R4 isandwherein R5 is selected from the group consisting of H, a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, or a hexyl group, and
wherein plasma extravasation in the subject is reduced upon administration of the compound or the pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate thereof.