Optical Biopsy Needle and Endoscope System

摘要

An interventional optical molecular imaging system and method are provided for use with a biopsy introducer needle. The system includes an imaging tool configured to slide coaxially through the biopsy introducer needle toward a tip of the biopsy introducer needle. The system also includes a laser illumination source coupled to the imaging tool, a camera configured to capture images from the imaging tool, and a computer coupled to the camera and the laser illumination source. The computer includes a processor configured to activate the laser illumination source to emit light through a tip of the imaging tool, collect imaging data from the camera after activating the laser illumination source, analyze the imaging data to determine a fluorescence measurement at the tip of the imaging tool, and display an indication of the fluorescence measurement.

主权项

1. An intraprocedural guidance method including steps comprising:
a) advancing an introducer needle percutaneously toward the pathologic tissue of the subject; b) before reaching the pathologic tissue, obtaining first imaging data of tissue adjacent to a tip of the introducer needle with an imaging tool inserted through the introducer needle; c) further advancing the introducer needle toward the pathologic tissue; d) obtaining second imaging data of tissue adjacent to the tip of the introducer needle with the imaging tool; e) comparing the first imaging data to the second imaging data to determine whether the tip of the introducer needle is at the pathologic tissue; and f) generating an output indicating to an operator whether the tip of the introducer needle is at the pathologic tissue.