发明名称 |
METHOD FOR IMPROVED HIGH SECRETORY PRODUCTION OF PROTEINS |
摘要 |
The present invention addresses the problem of providing a production system which achieves, in a host cell such as yeast, high secretory production of proteins, particularly proteins having a complex structure such as an S-S bond and which is so safe as to obviate explosion-proof equipment and is suitable for industrial production. The present invention provides a transformed yeast obtained by introducing a chaperone gene and disrupting aox1 and/or protease genes, and a method for producing proteins using the transformed yeast. |
申请公布号 |
WO2016017693(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
WO2015JP71503 |
申请日期 |
2015.07.29 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED;NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY |
发明人 |
NONAKA KOICHI;SUZUKI TAKESHI;TSUDA MASASHI;BABA SATOSHI;ICHIKAWA KIMIHISA;CHIBA YASUNORI;YOKO-O TAKEHIKO;ITO RIE |
分类号 |
C12N15/09;C12N1/19;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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