Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plama ratio of 20: 1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.
申请公布号
WO2016018795(A1)
申请公布日期
2016.02.04
申请号
WO2015US42206
申请日期
2015.07.27
申请人
THE GENERAL HOSPITAL CORPORATION
发明人
HOOKER, JACOB M.;WANG, CHANGNING;SCHROEDER, FREDERICK A.