| 发明名称 |
MULTI-EPITOPIC VACCINE |
| 摘要 |
The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases. |
| 申请公布号 |
US2016031946(A1) |
申请公布日期 |
2016.02.04 |
| 申请号 |
US201514883668 |
申请日期 |
2015.10.15 |
| 申请人 |
UNIVERSITE DE GENEVE ;HOPITAUX UNIVERSITAIRES DE GENEVE |
发明人 |
DEROUAZI MADIHA SABIHA;WALKER PAUL R.;DIETRICH PIERRE-YVES |
| 分类号 |
C07K14/005;C12N7/00;A61K39/245 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polypeptide comprising:
(i) a protein transduction domain consisting of ZEBRA consisting of amino acids residues 178-220 of ZEBRA or a fragment thereof or a variant thereof having at least one conservatively substituted amino acid from the native sequence, that retains the capacity of internalization, (ii) at least one CD4+ epitope(s); and (iii) at least one CD8+ epitope(s). |
| 地址 |
Geneva 4 CH |
