Alkyl 2--propionates, nucleoside inhibitors of HCV RNA-polymerase NS5B, methods for preparation and use thereof

摘要

Compounds of the general formula 1, stereoisomers, pharmaceutically acceptable salts, and/or hydrates, solvates or crystalline forms thereof;;wherein
R1 represents C1-C4 alkyl;
R2 and R3 represents fluoro, orR2 represents fluoro, and R3 represents methyl;R4 and R5 represents hydrogen, orR4 represents C1-C6 acyl, and R5 represents hydrogen, orR4 represents hydrogen, and R5 represents C1-C6 acyl, orR4 represents optionally substituted α-aminoacyl, and R5 represents hydrogen, orR4 represents hydrogen, and R5 represents optionally substituted α-aminoacyl;R6 represents hydrogen, methyl, methoxy or halogen.

主权项

1. Compounds of the general formula 1, or stereoisomers, pharmaceutically acceptable salts, and/or hydrates, solvates or crystalline forms thereofwhereinR1 represents C1-C4 alkyl;
R2 and R3 represents fluoro, or R2 represents fluoro, and R3 represents methyl; R4 and R5 represents hydrogen, or R4 represents C1-C6 acyl, and R5 represents hydrogen, or R4 represents hydrogen, and R5 represents C1-C6 acyl, or R4 represents hydrogen, and R5 represents optionally substituted α-aminoacyl, or R4 represents optionally substituted α-aminoacyl, and R5 represents hydrogen, or R6 represents hydrogen, methyl, methoxy or halogen.