OSMOTIC DRUG DELIVERY SYSTEM

摘要

An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.

主权项

1. An oral osmotic pharmaceutical delivery composition comprising an osmotically active drug core surrounded by a semi-permeable membrane,
wherein the osmotically active drug core comprises A) at least one release enhancing agent selected from a group consisting of wicking agents, complexing agents, and micelle-forming agents, and B) treprostinil or a pharmaceutically acceptable salt thereof having a water solubility of at least about 30 mg/mL, and wherein the semi-permeable membrane allows for the osmotic delivery of the treprostinil from the osmotically active drug core.