发明名称 |
RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER |
摘要 |
The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (VHH) or functional fragments thereof, wherein said VHH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions,for use in methods for the prevention and/or treatment of cancer. |
申请公布号 |
CA2954359(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
CA20152954359 |
申请日期 |
2015.07.17 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL |
发明人 |
LAHOUTTE, TONY;DEVOOGDT, NICK;D'HUYVETTER, MATTHIAS;DE VOS, JENS |
分类号 |
A61K51/10;A61K47/68;A61P35/00 |
主分类号 |
A61K51/10 |
代理机构 |
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地址 |
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