Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis

摘要

The present invention relates to a method for the prognosis of bone metastasis in renal cell carcinoma which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering renal cell carcinoma. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of renal cell carcinoma metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering renal cell carcinoma and for classifying a subject from renal cell carcinoma into a cohort.

主权项

1. An in vitro method for the diagnosis of metastasis in a subject with renal cell carcinoma and/or for the prognosis of the tendency to develop metastasis in a subject with renal cell carcinoma, said method comprising:
(i) quantifying the c-MAF gene expression level in a sample of said subject and (ii) comparing the expression level obtained in (i) with the expression level of the c-MAF gene in a control sample,wherein if the expression level of the c-MAF gene in said sample is increased with respect to the expression level of the c-MAF gene in the control sample, then said subject has a positive diagnosis for metastasis or a greater tendency to develop metastasis.