发明名称 |
SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY |
摘要 |
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases. |
申请公布号 |
WO2016016365(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
WO2015EP67501 |
申请日期 |
2015.07.30 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
OOST, THORSTEN;ANDERSKEWITZ, RALF;GNAMM, CHRISTIAN;HOESCH, HOLGER;MORSCHHAEUSER, GERD;PETERS, STEFAN;RIES, UWE JOERG |
分类号 |
C07D239/70;A61K31/517;A61P29/00 |
主分类号 |
C07D239/70 |
代理机构 |
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代理人 |
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地址 |
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