| 摘要 |
Disclosed herein are isolated major histocompatibility complex (MHC) class II al domain polypeptides and methods of use. In some embodiments, the isolated polypeptide comprises or consists of an MHC class H al domain polypeptide (or portion thereof) and does not include an MHC class II α2, β1, or β2 domain. The disclosed MHC class H al domain polypeptides are of use in treating or inhibiting disorders in a subject, such as inflammatory and/or autoimmune disorders. Also disclosed are methods of evaluating efficacy of treatment or optimizing treatment of a subject with a polypeptide including an MHC class II al domain polypeptide (or portion thereof) or a polypeptide including an MHC class II al domain and β1 domain (such as a β1α1 RTL). |
