发明名称 |
PHENYL DERIVATIVE |
摘要 |
An object of the present invention is to provide a compound having strong human S1P 2 antagonistic activity in order to develop a useful medicament for therapy of a S1P 2 -mediated disease such as a disease resulting from vascular constriction, fibrosis and respiratory disease. The compound represented by the general formula (I):
wherein all the symbols have the same meanings as described in the specification, has a halogen atom or a haloalkyl group and a phenoxy group at certain substitution sites, and thus has strong human S1P 2 antagonistic activity. Therefore, the compound can be a therapeutic agent for a S1P 2 -mediated disease, such as a disease resulting from vascular constriction, fibrosis and respiratory disease. |
申请公布号 |
EP2980072(A1) |
申请公布日期 |
2016.02.03 |
申请号 |
EP20140775353 |
申请日期 |
2014.03.25 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
KUSUMI, KENSUKE;NAGANAWA, ATSUSHI;OTSUKI, KAZUHIRO;SEKIGUCHI, TETSUYA;SHINOZAKI, KOJI;YAMAMOTO, HIROSHI;YAMAMOTO, YASUKO |
分类号 |
C07D207/12;A61K31/40;A61K31/451;A61P1/16;A61P3/06;A61P3/10;A61P9/00;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P13/12;A61P17/02;A61P19/02;A61P25/00;A61P25/04;A61P27/02;A61P27/06 |
主分类号 |
C07D207/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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