Pyrazole derivatives

摘要

Disclosed are pyrazole compounds of general formula (I), wherein R, R1, Rc, Rd, Re, Rf, X, Y, Z, A and B are as defined in the application. These compounds are active as inhibitors of poly(ADP-ribose)polymerase (PARP) and are useful in methods for treating diseases or conditions mediated by PARP, including breast cancer and malignant melanoma.;

主权项

1. A compound of general formula (I) or a pharmaceutically acceptable salt thereof: wherein: A and B together with carbons to which A and B attach represent optionally substituted C6-10 aryl, or optionally substituted C3-10 cyclohydrocarbyl; Rc,Rd, Re and Rf are independently selected from hydrogen, optionally substituted C1-6 alkyl and optionally substituted C1-6 acyl; R1 is independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl and optionally substituted C1-6 haloalkyl; R is independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-6 haloalkyl, C3-18 heterocyclyl optionally substituted with C1-6 alkyl or C1-6 haloalkyl or C3-12 cycloalkyl, optionally substituted C6-10 aryl, and optionally substituted C7-16 arylalkyl, wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulphur; and X represents oxygen or sulphur; Y and Z are independently selected from the group consisting of nitrogen, oxygen, sulphur and optionally substituted methylene, provided that when Y is oxygen or sulphur, then R1 is absent.