| 发明名称 | Antibodies directed to HER-3 and uses thereof | ||
| 摘要 | The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin. | ||
| 申请公布号 | US9249230(B2) | 申请公布日期 | 2016.02.02 |
| 申请号 | US200912365784 | 申请日期 | 2009.02.04 |
| 申请人 | U3 Pharma GmbH;Amgen Inc. | 发明人 | Rothe Mike;Treder Martin;Borges Eric;Hartmann Susanne;Green Larry L. |
| 分类号 | A61K39/395;C07K16/28;C07K16/32;G01N33/574;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Chao Hadidi Stark & Barker LLP | 代理人 | Chao Hadidi Stark & Barker LLP ;Millauer Birgit |
| 主权项 | 1. An isolated binding protein that binds to HER-3, comprising a heavy chain amino acid sequence that comprises a CDRH1 having the sequence of SEQ ID NO: 236, a CDRH2 having the sequence of SEQ ID NO: 258, and a CDRH3 having the sequence of SEQ ID NO: 283; and a light chain amino acid sequence that comprises a CDRL1 having the sequence of SEQ ID No: 320, a CDRL2 having the sequence of SEQ ID NO: 343, and a CDRL3 having the sequence of SEQ ID NO: 360. | ||
| 地址 | Martinsried DE | ||