| 发明名称 | Anti-EPHB4 antibodies and methods using same | ||
| 摘要 | The invention provides anti-EphB4 antibodies, and compositions comprising and methods of using these antibodies. | ||
| 申请公布号 | US9249222(B2) | 申请公布日期 | 2016.02.02 |
| 申请号 | US201213349503 | 申请日期 | 2012.01.12 |
| 申请人 | Genentech, Inc. | 发明人 | Wu Yan;Yan Minhong |
| 分类号 | A61K31/395;C07K16/28;A61K39/00;C07K16/30 | 主分类号 | A61K31/395 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method of inhibiting angiogenesis comprising administration of an effective amount of an anti-EphB4 antibody to a subject in need of such treatment, wherein the anti-EphrinB4 antibody comprises six hypervariable regions (HVRs) and wherein the antibody comprises HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2, and HVR-H3, wherein each, in order, comprises SEQ ID NO:9, 11, 15, 2, 4, and 7. | ||
| 地址 | South San Francisco CA US | ||