Human monoclonal antibody against <i>S. aureus </i>derived alpha-toxin and its use in treating or preventing abscess formation

摘要

The present invention includes a human monoclonal antibody specific for the alpha-toxin of S. aureus, a hybridoma producing it, nucleic acids encoding it, and host cells transfected therewith. Further, the present invention includes methods for producing the monoclonal antibody. In addition, the present invention includes pharmaceutical compositions comprising at least one antibody or at least one nucleic acid encoding the antibody. Further, the present invention includes the use of the monoclonal antibody for treating or preventing abscess formation.

主权项

1. A monoclonal antibody or binding fragment thereof specific for alpha-toxin of S. aureus, wherein the variable region of the light chain of the antibody comprises the amino acid sequence of SEQ ID NO: 27 and the variable region of the heavy chain comprises the amino acid sequence of SEQ ID NO: 8; wherein the antibody binding fragment is a Fab, F(ab′)2, single chain or domain antibody, and wherein the antibody or the binding fragment specifically binds to alpha-toxin of S. aureus.