| 摘要 |
Provided herein are compounds of formula A-L-B, and pharmaceutically acceptable salts and stereoisomers thereof, wherein
A is; wherein L, B and R3 are defined herein, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds and compositions provided herein are PDE-10 inhibitors and useful, e.g., for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes. |
| 主权项 |
1. A compound of formula (I):
A-L-B (I),or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
L is —(C(R10)2)m—, —CR10═CR10—, —K—C(R10)2—, —C(R10)2—K—, or —S—; K is —NR11—, —O—, or —S—; m is 2; A is B is B1 is O, S, or NR8; B2 is CR9 or N; each R3 is independently hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, amino, amido, or thiol; R4 and R5 together with the atoms to which they are attached form a monocyclic or multicyclic aryl, heteroaryl, cycloalkyl, or heterocyclyl ring; R6 is hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, amino, amido, or thiol; R7 is hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; R8 is hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; R9 is hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, amino, amido, or thiol; each R10 is independently hydrogen, halo, or alkyl; and each R11 is hydrogen or alkyl. |
