Derivatives of donepezil

摘要

This invention relates to novel compounds and hydrochloric acid salts thereof. More specifically, this invention relates to novel compounds and hydrochloric acid salts thereof derived from donepezil. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an acetylcholinesterase (AChE) inhibitor, such as donepezil.

主权项

1. A compound of Formula I, II or III: wherein: R1-R29 and X1-X4 are independently selected from hydrogen, deuterium, C1-12 alkyl, C1-12 alkoxy, aryloxy, trifluoromethyl, trifluoromethoxy, cyano, nitro, C1-12 alkylamino, C1-12 dialkylamino, C1-12 alkylthio, arylthio, C1-12 alkylcarbonyl, arylcarbonyl, C1-12 alkylcarboxy, arylcarboxy, C1-12 alkoxylcarboxy, aryloxylcarboxy, C1-12 alkanoylamino, arylcarbonylamino, C1-12 alkylcarbamido, arylcarbamido, C1-12 alkylaminocarboxy, arylaminocarboxy, trifluoroacetyl, halogen, C1-12 alkoxylcarbonyl, aryloxycarbonyl, C1-12 alkysulfinyl, arylsulfinyl, C1-12 alkylsulfonyl, arylsulfonyl, C1-12 alkylsulfonamido, arylsulfonamido, and aryl functional groups;
and wherein R14 in formula I is not hydrogen; or a N-oxide thereof; or a pharmaceutically acceptable salt thereof.