Rebamipide complexes and cocrystals

摘要

New rebamipide complexes and new rebamipide cocrystals are disclosed, specifically a 1:1 rebamipide nicotinamide complex, a 1:1 rebamipide nicotinamide cocrystal, a 1:1 rebamipide 2,4-dihydroxybenzolc acid complex, and a 1:1 rebamipide 2,4-dihydroxybenzoic acid cocrystal. Pharmaceutical compositions containing a rebamipide complex or cocrystal of the invention and a pharmaceutically acceptable carrier and methods of treatment are also disclosed.;

主权项

1. A 1:1 rebamipide nicotinamide cocrystal characterised by an x-ray powder diffraction pattern having at least three peaks selected from the peaks at 5.2, 9.5, 10.4, 11.5, 13.6, 16.0, 20.9 and 21.5 °2θ+0.2° 2θ.