Dose dispensing containers

摘要

Internally pierced formed blisters containing fluid compositions for use in devices to produce a spray or mist delivery of the compositions include internal piercing nozzles that can have significantly reduced channel volume to increase pressure of the fluid forced through the nozzle and provide finer control of spray geometry. The piercing nozzles are configured to deliver the contents of the blister to the central nervous system through the nasal olfactory epithelium.

主权项

1. A unit dose pharmaceutical delivery device comprising:
an internally pierced formed blister comprising:
a blister formed from a stretched flexible film material into a recess with an open end;a pierceable surface sealed to the open end of the blister to form an internal chamber enclosed by the formed recess; anda piercing nozzle wholly contained in the internal chamber, the piercing nozzle comprising:a base comprising an upper surface, a lower surface and a body,an elongated, substantially cylindrical member comprising exterior walls and projecting from the base at a first end and forming a swirl chamber and a discharge nozzle at a second end opposite the base attachment end;one or more internal channels formed in the interior of the elongated member and providing a fluid connection between the base and the swirl chamber, andone or more inlet openings in the upper surface of the base and one or more inlet channels providing a fluid connection from the one or more inlet openings to the one or more internal channels in the elongated member to provide a fluid path from the internal chamber, through the base, into the internal channels of the piercing nozzle, through the swirl chamber and out the discharge nozzle;wherein the piercing nozzle comprises internal structures configured to direct a liquid or powder contained in the blister to the cribriform plate, trigeminal nerve bundle or olfactory epithelium when administered intranasally to the recipient.