Nanopore molecule detection system and molecule detection method based on potential measurement of insulated conductive thin layer

摘要

A particle detector includes: a conductive nanolayer; insulating nanolayers attached to both sides of the conductive nanolayer; a nanopore formed to penetrate the conductive nanolayer and the insulating nanolayers so as to provide a migration path for a sample particle; a power supply unit configured to apply an electric field between both ends of the nanopore so as to apply a potential to the conductive nanolayer; and an electric signal measuring unit electrically connected to the conductive nanolayer and configured to measure the potential change in the conductive nanolayer induced by the sample particle as the sample particle migrates through the nanopore. The particle detector is capable of detecting a particle with high signal-to-noise ratio and resolution, scanning a sample without mechanical motion of the conductive nanolayer and analyzing DNA base sequences.

主权项

1. A particle detector comprising:
a single conductive nanolayer; insulating nanolayers attached to both sides of the conductive nanolayer; a nanopore formed to penetrate the conductive nanolayer and the insulating nanolayers so as to provide a migration path for a sample particle; a power supply unit comprising a pair of electrodes configured to apply an electric field between both ends of the nanopore so as to apply a potential between the single conductive nanolayer and one of the pair of electrodes, wherein the potential between the single conductive nanolayer and the one of the pair of electrodes is determined by spatial arrangement of the single conductive nanolayer between the pair of electrodes and power supplied from the power supply unit to the pair of electrodes; and an electric signal measuring unit electrically connected to one end of the single conductive nanolayer and configured to measure a change in the potential between the single conductive nanolayer and the one of the pair of electrodes to which the power is supplied, wherein the change in the potential between the single conductive nanolayer and the one of the pair of electrodes is induced by a resistance change of the nanopore above and below the sample particle as the sample particle migrates through the nanopore.