| 摘要 |
Disclosed are compounds of Formula (I), wherein: X is O or —NR3; R1 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CF2CH3, —CH2CH(CH3)CF3, —CH2CH2CH2F, or CH2(cyclopropyl); R2 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CH2F, —CH2CH(CH3)CF3, CH2CH2CF2CH3, —CH2(cyclopropyl), —CH(CH3)(cyclopropyl), phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridinyl, formula (i), formula (ii), formula (iii), formula (iv) or formula (v); Ring A is phenyl or pyridinyl; and R3, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.; |
| 主权项 |
1. A compound of Formula (I): wherein: X is O or —NR3; R1 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CF2CH3, —CH2CH(CH3)CF3, —CH2CH2CH2F, or —CH2(cyclopropyl); R2 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CH2F, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, —CH2(cyclopropyl), —CH(CH3)(cyclopropyl), phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridinyl, R3 is H, C1-3alkyl, —CH2CH2OH, or —CH2CH2OCH3; Ring A is phenyl or pyridinyl; each Ra is independently F, Cl, Br, C1-3 alkyl, —CH2OH, —CF3, —CN, cyclopropyl, —OCH3, —O(cyclopropyl), —OCH2CH2OCH3, and/or or two adjacent Ra along with the carbon atoms to which they are attached form a dioxole ring; each Rb is independently F, Cl, —CH3, —CH2OH, —CH2F, —CF3, cyclopropyl, and/or —OCH3; each Rc is independently H, F, Cl, and/or —CH3; n is 1 or 2; y is zero, 1, or 2; and z is zero, 1, or 2. |
