<i>Neisseria meningitidis </i>antigens and compositions

摘要

The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

主权项

1. A method of preparing an immunogenic composition comprising:
(a) expressing in E. coli a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO: 2534, wherein the fragment comprises 18 or more consecutive amino acids from the amino acid sequence, wherein the polypeptide is immunogenic; (b) purifying the polypeptide; (c) preparing the immunogenic composition by combining the purified polypeptide with an aluminum salt adjuvant.