| 发明名称 | Virus like particle composition | ||
| 摘要 | The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof. | ||
| 申请公布号 | US9249191(B2) | 申请公布日期 | 2016.02.02 |
| 申请号 | US201313768801 | 申请日期 | 2013.02.15 |
| 申请人 | VLP Therapeutics, LLC | 发明人 | Ueno Ryuji;Akahata Wataru |
| 分类号 | A61K39/12;C07K14/005;C07K14/525;C07K14/705;C12N7/00;A61K39/00 | 主分类号 | A61K39/12 |
| 代理机构 | Sughrue Mion, PLLC | 代理人 | Sughrue Mion, PLLC |
| 主权项 | 1. A Chikungunya virus (CHIKV) or Venezuelan equine encephalitis virus (VEEV) virus-like particle, wherein said virus-like particle contains at least one antigen inserted into an E2 envelope protein to form a fusion protein, wherein the at least one antigen is inserted within a CHIKV E2 envelope protein within a region that corresponds in position to residues 509-512, residues 519-520, or residues 529-533 of SEQ ID NO: 1 or 2; or wherein the at least one antigen is inserted within a VEEV E2 envelope protein within a region that corresponds in position to residues 515-520, or residues 536-539 of SEQ ID NO: 3. | ||
| 地址 | Wilmington DE US | ||