Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors

摘要

The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

主权项

1. The compound of Formula 1: wherein R1 is selected from the group consisting of H, F, and Cl; R2a and R2b are independently selected from the group consisting of H, F, Cl, Br, Me, OCH3, and cyano; R2c is selected from the group consisting of H, F, Cl, Br, Me, and OCH3; X is selected from the group consisting of A is selected from the group consisting of R3 is selected from the group consisting of F, Cl, Br, CH3, CF3, OCH3,cyano, N(CH3)2, and morpholino; n is selected from the group consisting of 0, 1, and 2; R4 is selected from the group consisting of H, F, Cl, Br, CH3, CF3, OCH3, cyano, N(CH3)2, and morpholino; with the proviso that when X is  and A is COOH, then at least one of R1, R2a, R2b, R2c, and R4 is not hydrogen, or n must be >0, and R3 when meta to naphthalene, cannot be CH3.