Process for the preparation of dronedarone by oxidation of a sulphenyl group

摘要

The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.;

主权项

1. A process for the preparation of dronedarone (I), or a pharmaceutically acceptable salt thereof, comprising the steps of: a) oxidizing a compound of formula (IV), or a salt thereof, with an oxidizing agent in an organic or inorganic solvent or solvent mixture; b) isolating dronedarone (I); and c) optionally converting dronedarone (I) into a pharmaceutically acceptable salt thereof.