| 发明名称 | Live-attenuated compositions for bacterial infections | ||
| 摘要 | The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity. | ||
| 申请公布号 | US9248175(B2) | 申请公布日期 | 2016.02.02 |
| 申请号 | US201414263276 | 申请日期 | 2014.04.28 |
| 申请人 | NORTHWESTERN UNIVERSITY | 发明人 | Klumpp David;Schaeffer Anthony;Billips Benjamin |
| 分类号 | A61K39/108;C12N1/20;A61K35/74;A61K35/744 | 主分类号 | A61K39/108 |
| 代理机构 | Casimir Jones, S.C. | 代理人 | Casimir Jones, S.C. ;Bond Jason |
| 主权项 | 1. A solid or semi-solid composition formulated for therapeutic administration to a subject via a suppository comprising: i) a sterilized carrier formulation selected from: an oily base, gelatin, and polyoxyethylene; and ii) a live attenuated uropathogenic E. coli strain with a non-functional or deleted waal gene such that said live attenuated uropathogenic E. coli strain is lacking O-antigen ligase function. | ||
| 地址 | Evanston IL US | ||