Catheter locking solution having antimicrobial and anticoagulation properties

摘要

The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

主权项

1. A catheter locking solution comprising:
a local anesthetic selected from the group consisting of dibucaine, tetracaine, and a combination thereof, in an amount effective to reduce microbial growth and coagulation in an implanted catheter; and a viscosifying agent, the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.