发明名称 Tris(hetero)arylpyrazoles and use thereof
摘要 The present invention relates to new tri(hetero)aryl pyrazoles, methods for their preparation, their use for treating and/or preventing diseases as well as their use in the preparation of drugs for treating and/or preventing diseases, in particular retroviral diseases in humans and/or animals.
申请公布号 US9249148(B2) 申请公布日期 2016.02.02
申请号 US201314422191 申请日期 2013.08.16
申请人 AICURIS GMBH & CO. KG 发明人 Wildum Steffen;Klenke Burkhard;Wendt Astrid
分类号 C07D403/02;C07D487/04;A61K31/4745;C07D471/04;C07D401/14;C07D403/04 主分类号 C07D403/02
代理机构 Millen White Zelano and Branigan, PC 代理人 Millen White Zelano and Branigan, PC ;Sopp John;Zelano Anthony
主权项 1. A compound of the formula wherein A stands for a group of the formula wherein U stands for NH, CH2 or C═O,V stands for N or CH,W stands for CH or CMe, wherein CMe stands for C—CH3,X stands for N or CH, and* is the point of attachment to the carbon atom, R1 stands for phenyl or pyridyl, whereby phenyl is substituted with 1 to 2 substituents, the substituents being selected independently of one another from the group consisting of halogen, cyano, methyl, trifluoromethyl, methoxy and trifluoromethoxy, whereby pyridyl can be substituted with 1 or 2 substituents, the substituents being selected independently of one another from the group consisting of halogen, methyl and trifluoromethyl, and whereby the nitrogen atom of the pyridyl can form an N oxide, and R2 stands for phenyl or pyridyl, whereby phenyl is substituted with 1 to 2 substituents, the substituents being selected independently of one another from the group consisting of halogen, cyano, (C1-C4)-alkyl and (C1-C4)-alkoxy, wherein alkyl and alkoxy in turn may be substituted with 1 to 3 fluorine atoms, whereby pyridyl can be substituted with 1 or 2 substituents, the substituents being selected independently of one another from the group consisting of halogen, cyano, (C1-C4)-alkyl, and (C1-C4)-alkoxy, and whereby the nitrogen atom of the pyridyl can form an N oxide, wherein alkyl and alkoxy in turn may be substituted with 1 to 3 fluorine atoms, or a salt thereof.
地址 Wuppertal DE