MRSA bactericidal topical gel

摘要

The present invention is directed to an enhanced wound healing composition, including a gel containing vancomycin, useful for the prevention of the spread of resistant-type bacteria. Preferably, the drug is one or more antibiotic agents in therapeutically effective concentrations to reduce or eliminate MRSA. The composition is based on a gel composition containing one or more gel forming compounds, such as one or more polymers, preservatives, and/or pH stabilizers and buffers, which not only maintains a moist wound environment to enhance wound healing, but also provides an antibiotic agent which has sustained potency and stability. The composition, when placed in contact with a treatment site, delivers the drug to the site. By incorporating the drug into the gel composition that is formulated to enhance wound healing, the treatment of such disease is possible in a manner which promotes wound healing while reducing or eliminating the MRSA microbe.

主权项

1. A topical bactericidal composition for the inhibition of microbial growth in a wound, characterized by an antibiotic agent which has sustained potency and stability comprising, in combination:
a wound healing composition comprising one or more polymers, one or more preservatives, one or more pH stabilizers and one or more buffers, which in combination, maintain sustained potency or stability of at least one antibiotic agent for at least a time period of between 1 month and 22 months; and at least one antibiotic agent in an effective amount for killing or preventing microbial growth of Methicillin-resistant Staphylococcus aureus (MRSA) within a wound site.