| 摘要 |
Disclosed are compounds used in the manufacture of a medicament for use in a method for the treatment of chemotherapy induced peripheral neuropathy (CIPN) in a subject, comprising administering to the subject an effective amount of poly(ADP-ribose)polymerase (PARP) inhibitors of the general formula (I), wherein the substituents are as described in the specification. In one embodiment the compound is 2-(2-methylpyrrolidin-2-yl)-lH-benzimidazole-4-carboxamide. In another embodiment the compound is 2-[(2R)-2-methylpyrrolidin-2-yl]-lH-benzimidazole-4-carboxamide. In yet another embodiment the compound is 2-[(2S)-2-methylpyrrolidin-2-yl]-lH-benzimidazole-4-carboxamide. |
