| 摘要 |
Disclosed is a flowable sustained release microparticulate composition, a kit for treating at least one cerebral artery in a subarachnoid space at risk of interruption due to a brain injury, a method of preparing the composition, and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury. The microparticulate composition comprises therapeutic agents, such as endothelin antagonists, transient receptor potential (TRP) protein antagonists, or dihydropyridine L-type voltage dependent calcium channel inhibitors selected from the group consisting of amlodipine, aranidipine, azelnidipine, bamidipine, benidipine, cinaldipine, efonidipine, felodipine, isradipine, lacidipine, lemildipine, lercanidipine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, manidipine, and pranidipine. The microparticulate composition further comprises slow release biodegradable polymers such as polylactide-polyglycolide, poly(orthoester), and poly(anhydride). |
