发明名称 |
PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER |
摘要 |
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed. |
申请公布号 |
HK1178563(A1) |
申请公布日期 |
2016.01.29 |
申请号 |
HK20130105243 |
申请日期 |
2013.04.30 |
申请人 |
UVIC INDUSTRY PARTNERSHIPS INC. |
发明人 |
DENMEADE, SAMUEL R;ISAACS, JOHN T;BUCKLEY, JAMES THOMAS |
分类号 |
C12N;C12N15/09;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P13/08;A61P35/00;C07K;C07K7/06;C07K14/195;C07K14/32;C07K14/325;C07K14/33;C07K14/47;C07K14/705;C07K19/00;C12N9/52 |
主分类号 |
C12N |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|