发明名称 |
Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
摘要 |
Discloses the use of a product comprising: (a) a first immunogenic composition comprising (i) at least a first immunogen or an immunogenic fragment thereof, and (ii) a TLR4 agonist, and (b) a second immunogenic composition comprising a lentiviral vector comprising a nucleotide sequence that encodes the first immunogen or an immunogenic fragment thereof, wherein the lentiviral vector is incorporated into a vector particle, wherein the vector particle comprises a lentiviral vector genome and an alpha virus envelope; in the manufacture of a medicament in the treatment of a subject requiring the priming and boosting of an immune response to said first immunogen. |
申请公布号 |
NZ616304(A) |
申请公布日期 |
2016.01.29 |
申请号 |
NZ20120616304 |
申请日期 |
2012.04.06 |
申请人 |
IMMUNE DESIGN CORP. |
发明人 |
DUBENSKY THOMAS W.;ROBBINS SCOTT H. |
分类号 |
A61K39/00;A61K9/107;A61K35/76;A61K39/02;A61K39/12;A61K39/39;A61K48/00;A61P31/04;A61P31/10;A61P31/12;A61P31/22;A61P33/00;A61P35/00;A61P37/04;A61P43/00;C07K14/435 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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