| 摘要 |
Provided are compounds of the general formula (I) wherein the variables are as defined in the specification. Examples of the compounds include Methyl 2-methyl-2-(5-methy1-6-(2,2,2-trifluoroethoxy)picolinamido)propanoate and (+)-5-Cyclopropy1-6-(2-methyl-propane-1-sulfony1)-pyridine-2-carboxylic acid [1-cyclopropy1-1-(5-methyl-[1,2,4]oxadiazol-3-y1)-ethyl]-amide. The compounds are agonists of Cannabinoid Receptor 2 (CB2). The compounds may be useful in the treatment of pain, atherosclerosis, regulation of bone mass, inflammation, ischemia, reperfusion injury, systemic fibrosis, liver fibrosis, lung fibrosis, kidney fibrosis, chronic allograft nephropathy, congestive heart failure, myocardial infarction, systemic sclerosis, glomerulonephropathy, thermal injury, burning, hypertrophic scars, keloids, gingivitis pyrexia, liver cirrhosis or tumors. |
