| 摘要 |
Disclosed is a process for the synthesis of calebin-A (STR#3) and its biologically active analogs comprising mixing the iodomethyl ketone (STR#1) of the ketone part of the compound with an aqueous solution of the sodium or potassium salt of the acid part of the compound (STR#2), stirring the mixture at ambient temperature in the presence of a phase transfer catalyst for 24-72 hours, and subsequently separating the organic layer from the product of step B, washing with aqueous sodium hydrogen carbonate solution, drying over sodium sulfate, filtering off the solvent and crystallising from ethyl acetate or ethanol. |
