ANTIBODIES AGAINST AMYLOID-BETA PEPTIDE

摘要

Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.

主权项

1. A method of treating Alzheimer's disease in a human patient comprising administering to the patient an effective amount of an isolated antibody or antigen binding fragment thereof which binds β-amyloid peptide and which comprises the following CDRs:CDRH1:(SEQ ID No: 1)DNGMACDRH2:(SEQ ID No: 2)FISNLAYSIDYADTVTGCDRH3:(SEQ ID No: 3)GTWFAY within a human heavy chain variable region originating from the VH3 gene family and:CDRL1:(SEQ ID No: 4)RVSQSLLHSNGYTYLHCDRL2:(SEQ ID No: 5)KVSNRFSCDRL3:(SEQ ID No: 6)SQTRHVPYT within a human light chain variable region originating from the amino acid sequence disclosed in GenPept entry CAA51135 (SEQ ID No:24).