INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)

摘要

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

主权项

1. A compound of formula (I)where
X is E is NH or CH2; W is N or CR10; Y is N or CR11; V is N or CR12;is an optionally substituted C3-C8 cycloalkyl;
R1 is optionally substituted aryl, optionally substituted aryl-C1-C10-alkyl, or optionally substituted C1-C10 alkyl; R2 is COOH, optionally substituted heteroaryl or optionally substituted —CONHSO2R14; R3 is H, optionally substituted C1-C10 alkyl or halo; R4 is H, optionally substituted C1-C10 alkyl, or halo; R6 is H; R7 and R8 are independently selected from optionally substituted C1-C10 alkyl, optionally substituted C1-C10 alkoxy, optionally substituted C1-C10-alkoxy-C1-C10-alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted aryl-C1-C10-alkyl, optionally substituted heteroaryl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, or optionally substituted C4-C8 cycloalkenyl; R9 is optionally substituted aryl, optionally substituted C1-C10 alkylaryl, optionally substituted C3-C8 cycloalkylaryl, optionally substituted C1-C10 alkoxyaryl, optionally substituted C1-C10 alkyl heteroaryl, optionally substituted heteroaryl, or optionally substituted R10 is H or halo; R11 is H or halo; and R12 is H, optionally substituted C1-C10 alkyl, or optionally substituted C2-C10 alkenyl; R14 is CF3, optionally substituted C3-C8 cycloalkyl or optionally substituted C1-C10 alkyl; and/or a stereoisomer, tautomer or a pharmaceutically acceptable salt thereof.