| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING CANCER |
| 摘要 |
Compositions containing one or more COX inhibitors in combination with one or more antagonists of 20-HETE (20-hydroxyeicosatetraeonic acid), and optionally a pharmaceutically acceptable excipient are provided. Preferred compositions include rofecoxib in combination with HET0016. The compositions have reduced side effects due to COX inhibitors. Methods for treating or inhibiting cancer using the disclosed compositions are also provided. |
| 申请公布号 |
US2016022614(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201514809859 |
申请日期 |
2015.07.27 |
| 申请人 |
Georgia Regents Research Institute, Inc. |
发明人 |
Wang Mong-Heng |
| 分类号 |
A61K31/155;A61K45/06;A61K31/365;A61K31/5575 |
主分类号 |
A61K31/155 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising an effective amount of a COX-2 inhibitor to inhibit cancer cell growth in a subject in need thereof in combination with a 20-Hydroxyeicosatetraenoic acid (20-HETE) antagonist in an effective amount to reduce or inhibit side effects of the COX-2 inhibitor in the subject. |
| 地址 |
Augusta GA US |
