发明名称 |
INHIBITORS OF FIBROPROLIFERATIVE DISORDERS AND CANCER |
摘要 |
The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compostions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGFβ receptor superfamily. |
申请公布号 |
WO2015183943(A3) |
申请公布日期 |
2016.01.28 |
申请号 |
WO2015US32658 |
申请日期 |
2015.05.27 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY |
发明人 |
LAYNE, MATTHEW D.;TUMELTY, KATHLEEN E.;LAFYATIS, BOB |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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