发明名称 |
NEW POLYCRYSTALLINE FORM OF TENOFOVIR PRODRUG, AND PREPARATION METHOD AND APPLICATION THEREFOR |
摘要 |
The present invention relates to a new crystalline form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine fumarate, and a preparation method and application therefor. Specifically, the present invention relates to a new crystalline form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine fumarate represented by formula (I), characterised in that the XRPD pattern of the crystalline form at least includes 2? ± 0.20o being: 5.08, 12.44, 13.18, 22.37, 23.37 and 28.56 diffraction peaks. The crystalline form of the present invention has features such as high bioavailability, significant efficacy, good stability, high yield and high purity, and contributes to the selection and design of a drug administration route and the determination of process parameters of a pharmaceutical preparation, thereby improving drug production quality. |
申请公布号 |
CA2954395(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
CA20152954395 |
申请日期 |
2015.07.21 |
申请人 |
JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. |
发明人 |
CHEN, MING;TIAN, CHENGYAO;ZHAO, MINGLI;YU, JUN;YANG, BAOHAI;LU, AIFENG |
分类号 |
C07F9/6561;A61K31/675;A61P31/18;A61P31/20 |
主分类号 |
C07F9/6561 |
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