FALZ FOR USE AS A TARGET FOR THERAPIES TO TREAT CANCER

摘要

The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of BPTF. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of BPTF between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising an inhibitory BPTF nucleic acid and/or an agent that inhibits the expression or activity of BPTF.

主权项

1. A method of prognosis of cancer, comprising:
(i) obtaining a biological sample from a subject; (ii) measuring the level of BPTF in the subject's sample comprising (a) performing quantitative RT-PCR using primer pairs to amplify BPTF or (b) converting RNA in the biological sample to aminoallyl-modified cDNA and labelling the cDNA with a dye followed by hybridizing the labeled cDNA to a microarray chip; (iii) comparing the level of BPTF in the subject's sample with the mean level of BPTF from one or more control biological samples; (iv) providing a prognosis that the subject may have cancer based on having a lower (or higher) level for BPTF in comparison to the mean level of BPTF in the controls.