OSTEOSARCOMA-ASSOCIATED RISK MARKERS AND USES THEREOF

摘要

Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed osteosarcoma. These subjects are identified based on the presence of germ-line risk markers.

主权项

1. A method, comprising:
a) analyzing genomic DNA from a canine subject for the presence of a single nucleotide polymorphism (SNP) selected from:
i) one or more chromosome 1 SNPs,ii) one or more chromosome 2 SNPs,iii) one or more chromosome 3 SNPs,iv) one or more chromosome 5 SNPs,v) one or more chromosome 7 SNPs,vi) one or more chromosome 8 SNPs,vii) one or more chromosome 9 SNPs,viii) one or more chromosome 11 SNPs,ix) one or more chromosome 13 SNPs,x) one or more chromosome 14 SNPs,xi) one or more chromosome 15 SNPs,xii) one or more chromosome 16 SNPs,xii) one or more chromosome 17 SNPs,xiv) one or more chromosome 18 SNPs,xv) one or more chromosome 19 SNPs,xvi) one or more chromosome 21 SNPs,xvii) one or more chromosome 25 SNPs,xvii) one or more chromosome 26 SNPs,xix) one or more chromosome 32 SNPs,xx) one or more chromosome 35 SNPs,xxi) one or more chromosome 36 SNPs, andxxii) one or more chromosome 38 SNPs; and b) identifying a canine subject having the SNP as a subject at elevated risk of developing osteosarcoma or having an undiagnosed osteosarcoma.