COMPOSITIONS AND METHODS FOR TREATING BONE DISEASES

摘要

Described herein are methods for treating bone diseases or defects. The methods include administering to a host animal therapeutically effective amounts of one or more compounds that are selective inhibitors of dephosphorylation of elF2a. Osteoblasts and osteoclasts are the two major types of bone cells in bone remodeling. It has also been discovered that the compounds described herein can regulate expression of NFATd at a transcriptional level. Silencing elF2a with RNA interference reduces suppression of salubrinal/guanabenz- driven downregulation of NFATd. Thus, the compounds described herein are useful in regulating bone remodeling through elF2a-nediated signainmg for combating bone loss in osteoporosis, and related diseases