| 主权项 |
1. A method of determining the probability that a prostate tissue biopsy obtained from a subject would contain detectable prostate cancer, the method comprising:
i) subjecting a blood sample of the subject to an immunoassay that measures a level of total prostate specific antigen (tPSA) in the blood sample; ii) if the tPSA level is above a threshold level, determining the probability that the prostate tissue biopsy would contain detectable prostate cancer by weighting the measured level of tPSA and a parameter indicative of whether the subject has had a prior biopsy of prostate tissue; and iii) if the tPSA level is at or below the threshold level, subjecting the blood sample to an immunoassay that measures levels of free prostate specific antigen (fPSA), intact prostate specific antigen (iPSA), and human kallikrein 2 (hK2) in the blood sample, and determining the probability that the prostate tissue biopsy would contain detectable prostate cancer by weighting the measured levels of tPSA, fPSA, iPSA, and hK2 and a parameter indicative of whether the subject has had a prior biopsy of prostate tissue. |
